diff --git a/rest_framework/settings.py b/rest_framework/settings.py
index 3f3c9110a..5682361fa 100644
--- a/rest_framework/settings.py
+++ b/rest_framework/settings.py
@@ -84,6 +84,7 @@ DEFAULTS = {
     # Exception handling
     'EXCEPTION_HANDLER': 'rest_framework.views.exception_handler',
     'NON_FIELD_ERRORS_KEY': 'non_field_errors',
+    'EXCEPTION_DETAIL_KEY': 'detail',
 
     # Testing
     'TEST_REQUEST_RENDERER_CLASSES': (
diff --git a/rest_framework/views.py b/rest_framework/views.py
index 8ec5f14ab..24d702f08 100644
--- a/rest_framework/views.py
+++ b/rest_framework/views.py
@@ -64,6 +64,7 @@ def exception_handler(exc, context):
     Any unhandled exceptions may return `None`, which will cause a 500 error
     to be raised.
     """
+    exception_detail_key = api_settings.EXCEPTION_DETAIL_KEY
     if isinstance(exc, exceptions.APIException):
         headers = {}
         if getattr(exc, 'auth_header', None):
@@ -74,21 +75,21 @@ def exception_handler(exc, context):
         if isinstance(exc.detail, (list, dict)):
             data = exc.detail
         else:
-            data = {'detail': exc.detail}
+            data = {exception_detail_key: exc.detail}
 
         set_rollback()
         return Response(data, status=exc.status_code, headers=headers)
 
     elif isinstance(exc, Http404):
         msg = _('Not found.')
-        data = {'detail': six.text_type(msg)}
+        data = {exception_detail_key: six.text_type(msg)}
 
         set_rollback()
         return Response(data, status=status.HTTP_404_NOT_FOUND)
 
     elif isinstance(exc, PermissionDenied):
         msg = _('Permission denied.')
-        data = {'detail': six.text_type(msg)}
+        data = {exception_detail_key: six.text_type(msg)}
 
         set_rollback()
         return Response(data, status=status.HTTP_403_FORBIDDEN)