diff --git a/rest_framework/response.py b/rest_framework/response.py
index 7a459c8f5..006d7eebb 100644
--- a/rest_framework/response.py
+++ b/rest_framework/response.py
@@ -45,3 +45,13 @@ class Response(SimpleTemplateResponse):
         # TODO: Deprecate and use a template tag instead
         # TODO: Status code text for RFC 6585 status codes
         return STATUS_CODE_TEXT.get(self.status_code, '')
+
+    def __getstate__(self):
+        """
+        Remove attributes from the response that shouldn't be cached
+        """
+        state = super(Response, self).__getstate__()
+        for key in ('accepted_renderer', 'renderer_context', 'data'):
+            if key in state:
+                del state[key]
+        return state
diff --git a/rest_framework/runtests/settings.py b/rest_framework/runtests/settings.py
index 951b1e72b..b48f85e4e 100644
--- a/rest_framework/runtests/settings.py
+++ b/rest_framework/runtests/settings.py
@@ -21,6 +21,12 @@ DATABASES = {
     }
 }
 
+CACHES = {
+    'default': {
+        'BACKEND': 'django.core.cache.backends.locmem.LocMemCache',
+    }
+}
+
 # Local time zone for this installation. Choices can be found here:
 # http://en.wikipedia.org/wiki/List_of_tz_zones_by_name
 # although not all choices may be available on all operating systems.
diff --git a/rest_framework/tests/renderers.py b/rest_framework/tests/renderers.py
index 48d8d9bd7..9be4b1146 100644
--- a/rest_framework/tests/renderers.py
+++ b/rest_framework/tests/renderers.py
@@ -1,6 +1,8 @@
+import pickle
 import re
 
 from django.conf.urls.defaults import patterns, url, include
+from django.core.cache import cache
 from django.test import TestCase
 from django.test.client import RequestFactory
 
@@ -83,6 +85,7 @@ class HTMLView1(APIView):
 urlpatterns = patterns('',
     url(r'^.*\.(?P<format>.+)$', MockView.as_view(renderer_classes=[RendererA, RendererB])),
     url(r'^$', MockView.as_view(renderer_classes=[RendererA, RendererB])),
+    url(r'^cache$', MockGETView.as_view()),
     url(r'^jsonp/jsonrenderer$', MockGETView.as_view(renderer_classes=[JSONRenderer, JSONPRenderer])),
     url(r'^jsonp/nojsonrenderer$', MockGETView.as_view(renderer_classes=[JSONPRenderer])),
     url(r'^html$', HTMLView.as_view()),
@@ -416,3 +419,89 @@ class XMLRendererTestCase(TestCase):
         self.assertTrue(xml.startswith('<?xml version="1.0" encoding="utf-8"?>\n<root>'))
         self.assertTrue(xml.endswith('</root>'))
         self.assertTrue(string in xml, '%r not in %r' % (string, xml))
+
+
+# Tests for caching issue, #346
+class CacheRenderTest(TestCase):
+    """
+    Tests specific to caching responses
+    """
+
+    urls = 'rest_framework.tests.renderers'
+
+    cache_key = 'just_a_cache_key'
+
+    @classmethod
+    def _get_pickling_errors(cls, obj, seen=None):
+        """ Return any errors that would be raised if `obj' is pickled
+        Courtesy of koffie @ http://stackoverflow.com/a/7218986/109897
+        """
+        if seen == None:
+            seen = []
+        try:
+            state = obj.__getstate__()
+        except AttributeError:
+            return
+        if state == None:
+            return
+        if isinstance(state,tuple):
+            if not isinstance(state[0],dict):
+                state=state[1]
+            else:
+                state=state[0].update(state[1])
+        result = {}
+        for i in state:
+            try:
+                pickle.dumps(state[i],protocol=2)
+            except pickle.PicklingError:
+                if not state[i] in seen:
+                    seen.append(state[i])
+                    result[i] = cls._get_pickling_errors(state[i],seen)
+        return result
+
+    def http_resp(self, http_method, url):
+        """
+        Simple wrapper for Client http requests
+        Removes the `client' and `request' attributes from as they are
+        added by django.test.client.Client and not part of caching
+        responses outside of tests.
+        """
+        method = getattr(self.client, http_method)
+        resp = method(url)
+        del resp.client, resp.request
+        return resp
+
+    def test_obj_pickling(self):
+        """
+        Test that responses are properly pickled
+        """
+        resp = self.http_resp('get', '/cache')
+
+        # Make sure that no pickling errors occurred
+        self.assertEqual(self._get_pickling_errors(resp), {})
+
+        # Unfortunately LocMem backend doesn't raise PickleErrors but returns
+        # None instead.
+        cache.set(self.cache_key, resp)
+        self.assertTrue(cache.get(self.cache_key) is not None)
+
+    def test_head_caching(self):
+        """
+        Test caching of HEAD requests
+        """
+        resp = self.http_resp('head', '/cache')
+        cache.set(self.cache_key, resp)
+
+        cached_resp = cache.get(self.cache_key)
+        self.assertIsInstance(cached_resp, Response)
+
+    def test_get_caching(self):
+        """
+        Test caching of GET requests
+        """
+        resp = self.http_resp('get', '/cache')
+        cache.set(self.cache_key, resp)
+
+        cached_resp = cache.get(self.cache_key)
+        self.assertIsInstance(cached_resp, Response)
+        self.assertEqual(cached_resp.content, resp.content)