diff --git a/rest_framework/status.py b/rest_framework/status.py
index df0fa0f02..3ae68ec36 100644
--- a/rest_framework/status.py
+++ b/rest_framework/status.py
@@ -64,6 +64,7 @@ HTTP_414_REQUEST_URI_TOO_LONG = 414
 HTTP_415_UNSUPPORTED_MEDIA_TYPE = 415
 HTTP_416_REQUESTED_RANGE_NOT_SATISFIABLE = 416
 HTTP_417_EXPECTATION_FAILED = 417
+HTTP_421_MISDIRECTED_REQUEST = 421
 HTTP_422_UNPROCESSABLE_ENTITY = 422
 HTTP_423_LOCKED = 423
 HTTP_424_FAILED_DEPENDENCY = 424