diff --git a/docs/main/changelog.rst b/docs/main/changelog.rst
index bfc873e8..80a6c133 100644
--- a/docs/main/changelog.rst
+++ b/docs/main/changelog.rst
@@ -9,13 +9,16 @@ follows `Semantic versioning`_
 
 Development version
 -------------------
+- Introduce wiring inspect filter to filter out ``flask.request`` and other local proxy objects
+  from the inspection.
+  See issue: `#408 <https://github.com/ets-labs/python-dependency-injector/issues/408>`_.
+  Many thanks to `@bvanfleet <https://github.com/bvanfleet>`_ for reporting the issue and
+  help in finding the root cause.
 - Add ``boto3`` example.
 - Add tests for ``.as_float()`` modifier usage with wiring.
 - Make refactoring of wiring module and tests.
   See PR # `#406 <https://github.com/ets-labs/python-dependency-injector/issues/406>`_.
   Thanks to `@withshubh <https://github.com/withshubh>`_ for the contribution:
-    - Refactor unnecessary ``else`` / ``elif`` in ``wiring`` module when ``if`` block has a
-      return statement.
     - Remove unused imports in tests.
     - Use literal syntax to create data structure in tests.
 - Add integration with a static analysis tool `DeepSource <https://deepsource.io/>`_.
diff --git a/src/dependency_injector/wiring.py b/src/dependency_injector/wiring.py
index 96d1e238..c5a591da 100644
--- a/src/dependency_injector/wiring.py
+++ b/src/dependency_injector/wiring.py
@@ -37,10 +37,21 @@ else:
 
 
 try:
-    from fastapi.params import Depends as FastAPIDepends
-    fastapi_installed = True
+    import fastapi.params
 except ImportError:
-    fastapi_installed = False
+    fastapi = None
+
+
+try:
+    import starlette.requests
+except ImportError:
+    starlette = None
+
+
+try:
+    import werkzeug.local
+except ImportError:
+    werkzeug = None
 
 
 from . import providers
@@ -111,20 +122,21 @@ class ProvidersMap:
     ) -> Optional[providers.Provider]:
         if isinstance(provider, providers.Delegate):
             return self._resolve_delegate(provider)
-        if isinstance(provider, (
+        elif isinstance(provider, (
             providers.ProvidedInstance,
             providers.AttributeGetter,
             providers.ItemGetter,
             providers.MethodCaller,
         )):
             return self._resolve_provided_instance(provider)
-        if isinstance(provider, providers.ConfigurationOption):
+        elif isinstance(provider, providers.ConfigurationOption):
             return self._resolve_config_option(provider)
-        if isinstance(provider, providers.TypedConfigurationOption):
+        elif isinstance(provider, providers.TypedConfigurationOption):
             return self._resolve_config_option(provider.option, as_=provider.provides)
-        if isinstance(provider, str):
+        elif isinstance(provider, str):
             return self._resolve_string_id(provider, modifier)
-        return self._resolve_provider(provider)
+        else:
+            return self._resolve_provider(provider)
 
     def _resolve_string_id(
             self,
@@ -247,6 +259,28 @@ class ProvidersMap:
         return providers_map
 
 
+class InspectFilter:
+
+    def is_excluded(self, instance: object) -> bool:
+        if self._is_werkzeug_local_proxy(instance):
+            return True
+        elif self._is_starlette_request_cls(instance):
+            return True
+        else:
+            return False
+
+    def _is_werkzeug_local_proxy(self, instance: object) -> bool:
+        return werkzeug and isinstance(instance, werkzeug.local.LocalProxy)
+
+    def _is_starlette_request_cls(self, instance: object) -> bool:
+        return starlette \
+               and isinstance(instance, type) \
+               and issubclass(instance, starlette.requests.Request)
+
+
+inspect_filter = InspectFilter()
+
+
 def wire(  # noqa: C901
         container: Container,
         *,
@@ -268,6 +302,8 @@ def wire(  # noqa: C901
 
     for module in modules:
         for name, member in inspect.getmembers(module):
+            if inspect_filter.is_excluded(member):
+                continue
             if inspect.isfunction(member):
                 _patch_fn(module, name, member, providers_map)
             elif inspect.isclass(member):
@@ -530,7 +566,7 @@ def _is_fastapi_default_arg_injection(injection, kwargs):
 
 
 def _is_fastapi_depends(param: Any) -> bool:
-    return fastapi_installed and isinstance(param, FastAPIDepends)
+    return fastapi and isinstance(param, fastapi.params.Depends)
 
 
 def _is_patched(fn):
diff --git a/tests/unit/samples/wiringflask/web.py b/tests/unit/samples/wiringflask/web.py
new file mode 100644
index 00000000..59b5d004
--- /dev/null
+++ b/tests/unit/samples/wiringflask/web.py
@@ -0,0 +1,34 @@
+import sys
+
+from flask import Flask, jsonify, request, current_app, session, g
+from flask import _request_ctx_stack, _app_ctx_stack
+from dependency_injector import containers, providers
+from dependency_injector.wiring import inject, Provide
+
+# This is here for testing wiring bypasses these objects without crashing
+request, current_app, session, g  # noqa
+_request_ctx_stack, _app_ctx_stack  # noqa
+
+
+class Service:
+    def process(self) -> str:
+        return 'Ok'
+
+
+class Container(containers.DeclarativeContainer):
+
+    service = providers.Factory(Service)
+
+
+app = Flask(__name__)
+
+
+@app.route('/')
+@inject
+def index(service: Service = Provide[Container.service]):
+    result = service.process()
+    return jsonify({'result': result})
+
+
+container = Container()
+container.wire(modules=[sys.modules[__name__]])
diff --git a/tests/unit/wiring/test_wiringflask_py36.py b/tests/unit/wiring/test_wiringflask_py36.py
new file mode 100644
index 00000000..1eaaa4d8
--- /dev/null
+++ b/tests/unit/wiring/test_wiringflask_py36.py
@@ -0,0 +1,33 @@
+import unittest
+
+# Runtime import to avoid syntax errors in samples on Python < 3.5 and reach top-dir
+import os
+_TOP_DIR = os.path.abspath(
+    os.path.sep.join((
+        os.path.dirname(__file__),
+        '../',
+    )),
+)
+_SAMPLES_DIR = os.path.abspath(
+    os.path.sep.join((
+        os.path.dirname(__file__),
+        '../samples/',
+    )),
+)
+import sys
+sys.path.append(_TOP_DIR)
+sys.path.append(_SAMPLES_DIR)
+
+from wiringflask import web
+
+
+class WiringFlaskTest(unittest.TestCase):
+
+    def test(self):
+        client = web.app.test_client()
+
+        with web.app.app_context():
+            response = client.get('/')
+
+        self.assertEqual(response.status_code, 200)
+        self.assertEqual(response.data, b'{"result":"Ok"}\n')