Python 2.7 Windows build has been tested with the following toolchain: - Python 2.7.10 :) - Microsoft Visual C++ Compiler Package for Python 2.7 http://www.microsoft.com/en-us/download/details.aspx?id=44266 - C99 compliant stdint.h for MSVC https://msinttypes.googlecode.com/svn/trunk/stdint.h (C99 complian stdint.h header which is not supplied with Microsoft Visual C++ compiler prior to MSVC 2010) Build steps: - pip install --upgrade setuptools - pip install cython fabric fabtools - pip install -r requirements.txt - python pip install -e . If you are using traditional Microsoft SDK (v7.0 for Python 2.x or v7.1 for Python 3.x) consider run_with_env.cmd from appveyor folder (submodule) as a guideline for environment setup. It can be also used as shell conviguration script for your build, install and run commands, i.e.: cmd /E:ON /V:ON /C run_with_env.cmd