diff --git a/graphene/relay/node.py b/graphene/relay/node.py
index 571f8b5c..f8927ab7 100644
--- a/graphene/relay/node.py
+++ b/graphene/relay/node.py
@@ -90,13 +90,25 @@ class Node(AbstractNode):
     def get_node_from_global_id(cls, info, global_id, only_type=None):
         try:
             _type, _id = cls.from_global_id(global_id)
-            graphene_type = info.schema.get_type(_type).graphene_type
         except Exception as e:
             raise Exception(
-                "Unable to call from_global_id, is the id a base64 encoding of 'TypeName:id': {} Exception: {}".format(
-                    str(global_id), str(e)
+                (
+                    'Unable to parse global ID "{global_id}". '
+                    'Make sure it is a base64 encoded string in the format: "TypeName:id". '
+                    "Exception message: {exception}".format(
+                        global_id=global_id, exception=str(e)
+                    )
                 )
             )
+
+        graphene_type = info.schema.get_type(_type)
+        if graphene_type is None:
+            raise Exception(
+                'Relay Node "{_type}" not found in schema'.format(_type=_type)
+            )
+
+        graphene_type = graphene_type.graphene_type
+
         if only_type:
             assert graphene_type == only_type, ("Must receive a {} id.").format(
                 only_type._meta.name
@@ -104,7 +116,11 @@ class Node(AbstractNode):
 
         # We make sure the ObjectType implements the "Node" interface
         if cls not in graphene_type._meta.interfaces:
-            return None
+            raise Exception(
+                'ObjectType "{_type}" does not implement the "{cls}" interface.'.format(
+                    _type=_type, cls=cls
+                )
+            )
 
         get_node = getattr(graphene_type, "get_node", None)
         if get_node:
diff --git a/graphene/relay/tests/test_node.py b/graphene/relay/tests/test_node.py
index 279b930e..de1802e9 100644
--- a/graphene/relay/tests/test_node.py
+++ b/graphene/relay/tests/test_node.py
@@ -1,3 +1,4 @@
+import re
 from graphql_relay import to_global_id
 
 from graphql.pyutils import dedent
@@ -83,6 +84,20 @@ def test_node_requesting_non_node():
     executed = schema.execute(
         '{ node(id:"%s") { __typename } } ' % Node.to_global_id("RootQuery", 1)
     )
+    assert executed.errors
+    assert re.match(
+        r"ObjectType .* does not implement the .* interface.",
+        executed.errors[0].message,
+    )
+    assert executed.data == {"node": None}
+
+
+def test_node_requesting_unknown_type():
+    executed = schema.execute(
+        '{ node(id:"%s") { __typename } } ' % Node.to_global_id("UnknownType", 1)
+    )
+    assert executed.errors
+    assert re.match(r"Relay Node .* not found in schema", executed.errors[0].message)
     assert executed.data == {"node": None}
 
 
@@ -91,6 +106,7 @@ def test_node_query_incorrect_id():
         '{ node(id:"%s") { ... on MyNode { name } } }' % "something:2"
     )
     assert executed.errors
+    assert re.match(r"Unable to parse global ID .*", executed.errors[0].message)
     assert executed.data == {"node": None}