diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index 51832084..9df18f99 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -58,7 +58,7 @@ jobs:
         if: ${{ matrix.python == '3.10' }}
         uses: actions/upload-artifact@v3
         with:
-          name: graphene-sqlalchemy-coverage
+          name: graphene-coverage
           path: coverage.xml
           if-no-files-found: error
       - name: Upload coverage.xml to codecov
diff --git a/Makefile b/Makefile
index c78e2b4f..08947707 100644
--- a/Makefile
+++ b/Makefile
@@ -7,6 +7,7 @@ help:
 install-dev:
 	pip install -e ".[dev]"
 
+.PHONY: test ## Run tests
 test:
 	py.test graphene examples
 
diff --git a/graphene/__init__.py b/graphene/__init__.py
index aeb6d6d2..af83f059 100644
--- a/graphene/__init__.py
+++ b/graphene/__init__.py
@@ -1,11 +1,15 @@
 from .pyutils.version import get_version
 from .relay import (
+    BaseGlobalIDType,
     ClientIDMutation,
     Connection,
     ConnectionField,
+    DefaultGlobalIDType,
     GlobalID,
     Node,
     PageInfo,
+    SimpleGlobalIDType,
+    UUIDGlobalIDType,
     is_node,
 )
 from .types import (
@@ -52,6 +56,7 @@ __all__ = [
     "Argument",
     "Base64",
     "BigInt",
+    "BaseGlobalIDType",
     "Boolean",
     "ClientIDMutation",
     "Connection",
@@ -60,6 +65,7 @@ __all__ = [
     "Date",
     "DateTime",
     "Decimal",
+    "DefaultGlobalIDType",
     "Dynamic",
     "Enum",
     "Field",
@@ -80,10 +86,12 @@ __all__ = [
     "ResolveInfo",
     "Scalar",
     "Schema",
+    "SimpleGlobalIDType",
     "String",
     "Time",
-    "UUID",
     "Union",
+    "UUID",
+    "UUIDGlobalIDType",
     "is_node",
     "lazy_import",
     "resolve_only_args",
diff --git a/graphene/relay/__init__.py b/graphene/relay/__init__.py
index 7238fa72..3b842cf5 100644
--- a/graphene/relay/__init__.py
+++ b/graphene/relay/__init__.py
@@ -1,13 +1,23 @@
 from .node import Node, is_node, GlobalID
 from .mutation import ClientIDMutation
 from .connection import Connection, ConnectionField, PageInfo
+from .id_type import (
+    BaseGlobalIDType,
+    DefaultGlobalIDType,
+    SimpleGlobalIDType,
+    UUIDGlobalIDType,
+)
 
 __all__ = [
-    "Node",
-    "is_node",
-    "GlobalID",
+    "BaseGlobalIDType",
     "ClientIDMutation",
     "Connection",
     "ConnectionField",
+    "DefaultGlobalIDType",
+    "GlobalID",
+    "Node",
     "PageInfo",
+    "SimpleGlobalIDType",
+    "UUIDGlobalIDType",
+    "is_node",
 ]
diff --git a/graphene/relay/id_type.py b/graphene/relay/id_type.py
new file mode 100644
index 00000000..fb5c30e7
--- /dev/null
+++ b/graphene/relay/id_type.py
@@ -0,0 +1,87 @@
+from graphql_relay import from_global_id, to_global_id
+
+from ..types import ID, UUID
+from ..types.base import BaseType
+
+from typing import Type
+
+
+class BaseGlobalIDType:
+    """
+    Base class that define the required attributes/method for a type.
+    """
+
+    graphene_type = ID  # type: Type[BaseType]
+
+    @classmethod
+    def resolve_global_id(cls, info, global_id):
+        # return _type, _id
+        raise NotImplementedError
+
+    @classmethod
+    def to_global_id(cls, _type, _id):
+        # return _id
+        raise NotImplementedError
+
+
+class DefaultGlobalIDType(BaseGlobalIDType):
+    """
+    Default global ID type: base64 encoded version of "<node type name>: <node id>".
+    """
+
+    graphene_type = ID
+
+    @classmethod
+    def resolve_global_id(cls, info, global_id):
+        try:
+            _type, _id = from_global_id(global_id)
+            if not _type:
+                raise ValueError("Invalid Global ID")
+            return _type, _id
+        except Exception as e:
+            raise Exception(
+                f'Unable to parse global ID "{global_id}". '
+                'Make sure it is a base64 encoded string in the format: "TypeName:id". '
+                f"Exception message: {e}"
+            )
+
+    @classmethod
+    def to_global_id(cls, _type, _id):
+        return to_global_id(_type, _id)
+
+
+class SimpleGlobalIDType(BaseGlobalIDType):
+    """
+    Simple global ID type: simply the id of the object.
+    To be used carefully as the user is responsible for ensuring that the IDs are indeed global
+    (otherwise it could cause request caching issues).
+    """
+
+    graphene_type = ID
+
+    @classmethod
+    def resolve_global_id(cls, info, global_id):
+        _type = info.return_type.graphene_type._meta.name
+        return _type, global_id
+
+    @classmethod
+    def to_global_id(cls, _type, _id):
+        return _id
+
+
+class UUIDGlobalIDType(BaseGlobalIDType):
+    """
+    UUID global ID type.
+    By definition UUID are global so they are used as they are.
+    """
+
+    graphene_type = UUID
+
+    @classmethod
+    def resolve_global_id(cls, info, global_id):
+        _type = info.return_type.graphene_type._meta.name
+        return _type, global_id
+
+    @classmethod
+    def to_global_id(cls, _type, _id):
+        return _id
diff --git a/graphene/relay/node.py b/graphene/relay/node.py
index dabcff6c..54438281 100644
--- a/graphene/relay/node.py
+++ b/graphene/relay/node.py
@@ -1,11 +1,10 @@
 from functools import partial
 from inspect import isclass
 
-from graphql_relay import from_global_id, to_global_id
-
-from ..types import ID, Field, Interface, ObjectType
+from ..types import Field, Interface, ObjectType
 from ..types.interface import InterfaceOptions
 from ..types.utils import get_type
+from .id_type import BaseGlobalIDType, DefaultGlobalIDType
 
 
 def is_node(objecttype):
@@ -22,8 +21,18 @@ def is_node(objecttype):
 
 
 class GlobalID(Field):
-    def __init__(self, node=None, parent_type=None, required=True, *args, **kwargs):
-        super(GlobalID, self).__init__(ID, required=required, *args, **kwargs)
+    def __init__(
+        self,
+        node=None,
+        parent_type=None,
+        required=True,
+        global_id_type=DefaultGlobalIDType,
+        *args,
+        **kwargs,
+    ):
+        super(GlobalID, self).__init__(
+            global_id_type.graphene_type, required=required, *args, **kwargs
+        )
         self.node = node or Node
         self.parent_type_name = parent_type._meta.name if parent_type else None
 
@@ -47,12 +56,14 @@ class NodeField(Field):
         assert issubclass(node, Node), "NodeField can only operate in Nodes"
         self.node_type = node
         self.field_type = type_
+        global_id_type = node._meta.global_id_type
 
         super(NodeField, self).__init__(
-            # If we don's specify a type, the field type will be the node
-            # interface
+            # If we don't specify a type, the field type will be the node interface
             type_ or node,
-            id=ID(required=True, description="The ID of the object"),
+            id=global_id_type.graphene_type(
+                required=True, description="The ID of the object"
+            ),
             **kwargs,
         )
 
@@ -65,11 +76,23 @@ class AbstractNode(Interface):
         abstract = True
 
     @classmethod
-    def __init_subclass_with_meta__(cls, **options):
+    def __init_subclass_with_meta__(cls, global_id_type=DefaultGlobalIDType, **options):
+        assert issubclass(
+            global_id_type, BaseGlobalIDType
+        ), "Custom ID type need to be implemented as a subclass of BaseGlobalIDType."
         _meta = InterfaceOptions(cls)
-        _meta.fields = {"id": GlobalID(cls, description="The ID of the object")}
+        _meta.global_id_type = global_id_type
+        _meta.fields = {
+            "id": GlobalID(
+                cls, global_id_type=global_id_type, description="The ID of the object"
+            )
+        }
         super(AbstractNode, cls).__init_subclass_with_meta__(_meta=_meta, **options)
 
+    @classmethod
+    def resolve_global_id(cls, info, global_id):
+        return cls._meta.global_id_type.resolve_global_id(info, global_id)
+
 
 class Node(AbstractNode):
     """An object with an ID"""
@@ -84,16 +107,7 @@ class Node(AbstractNode):
 
     @classmethod
     def get_node_from_global_id(cls, info, global_id, only_type=None):
-        try:
-            _type, _id = cls.from_global_id(global_id)
-            if not _type:
-                raise ValueError("Invalid Global ID")
-        except Exception as e:
-            raise Exception(
-                f'Unable to parse global ID "{global_id}". '
-                'Make sure it is a base64 encoded string in the format: "TypeName:id". '
-                f"Exception message: {e}"
-            )
+        _type, _id = cls.resolve_global_id(info, global_id)
 
         graphene_type = info.schema.get_type(_type)
         if graphene_type is None:
@@ -116,10 +130,6 @@ class Node(AbstractNode):
         if get_node:
             return get_node(info, _id)
 
-    @classmethod
-    def from_global_id(cls, global_id):
-        return from_global_id(global_id)
-
     @classmethod
     def to_global_id(cls, type_, id):
-        return to_global_id(type_, id)
+        return cls._meta.global_id_type.to_global_id(type_, id)
diff --git a/graphene/relay/tests/test_custom_global_id.py b/graphene/relay/tests/test_custom_global_id.py
new file mode 100644
index 00000000..c1bf0fb4
--- /dev/null
+++ b/graphene/relay/tests/test_custom_global_id.py
@@ -0,0 +1,325 @@
+import re
+from uuid import uuid4
+
+from graphql import graphql_sync
+
+from ..id_type import BaseGlobalIDType, SimpleGlobalIDType, UUIDGlobalIDType
+from ..node import Node
+from ...types import Int, ObjectType, Schema, String
+
+
+class TestUUIDGlobalID:
+    def setup(self):
+        self.user_list = [
+            {"id": uuid4(), "name": "First"},
+            {"id": uuid4(), "name": "Second"},
+            {"id": uuid4(), "name": "Third"},
+            {"id": uuid4(), "name": "Fourth"},
+        ]
+        self.users = {user["id"]: user for user in self.user_list}
+
+        class CustomNode(Node):
+            class Meta:
+                global_id_type = UUIDGlobalIDType
+
+        class User(ObjectType):
+            class Meta:
+                interfaces = [CustomNode]
+
+            name = String()
+
+            @classmethod
+            def get_node(cls, _type, _id):
+                return self.users[_id]
+
+        class RootQuery(ObjectType):
+            user = CustomNode.Field(User)
+
+        self.schema = Schema(query=RootQuery, types=[User])
+        self.graphql_schema = self.schema.graphql_schema
+
+    def test_str_schema_correct(self):
+        """
+        Check that the schema has the expected and custom node interface and user type and that they both use UUIDs
+        """
+        parsed = re.findall(r"(.+) \{\n\s*([\w\W]*?)\n\}", str(self.schema))
+        types = [t for t, f in parsed]
+        fields = [f for t, f in parsed]
+        custom_node_interface = "interface CustomNode"
+        assert custom_node_interface in types
+        assert (
+            '"""The ID of the object"""\n  id: UUID!'
+            == fields[types.index(custom_node_interface)]
+        )
+        user_type = "type User implements CustomNode"
+        assert user_type in types
+        assert (
+            '"""The ID of the object"""\n  id: UUID!\n  name: String'
+            == fields[types.index(user_type)]
+        )
+
+    def test_get_by_id(self):
+        query = """query userById($id: UUID!) {
+            user(id: $id) {
+                id
+                name
+            }
+        }"""
+        # UUID need to be converted to string for serialization
+        result = graphql_sync(
+            self.graphql_schema,
+            query,
+            variable_values={"id": str(self.user_list[0]["id"])},
+        )
+        assert not result.errors
+        assert result.data["user"]["id"] == str(self.user_list[0]["id"])
+        assert result.data["user"]["name"] == self.user_list[0]["name"]
+
+
+class TestSimpleGlobalID:
+    def setup(self):
+        self.user_list = [
+            {"id": "my global primary key in clear 1", "name": "First"},
+            {"id": "my global primary key in clear 2", "name": "Second"},
+            {"id": "my global primary key in clear 3", "name": "Third"},
+            {"id": "my global primary key in clear 4", "name": "Fourth"},
+        ]
+        self.users = {user["id"]: user for user in self.user_list}
+
+        class CustomNode(Node):
+            class Meta:
+                global_id_type = SimpleGlobalIDType
+
+        class User(ObjectType):
+            class Meta:
+                interfaces = [CustomNode]
+
+            name = String()
+
+            @classmethod
+            def get_node(cls, _type, _id):
+                return self.users[_id]
+
+        class RootQuery(ObjectType):
+            user = CustomNode.Field(User)
+
+        self.schema = Schema(query=RootQuery, types=[User])
+        self.graphql_schema = self.schema.graphql_schema
+
+    def test_str_schema_correct(self):
+        """
+        Check that the schema has the expected and custom node interface and user type and that they both use UUIDs
+        """
+        parsed = re.findall(r"(.+) \{\n\s*([\w\W]*?)\n\}", str(self.schema))
+        types = [t for t, f in parsed]
+        fields = [f for t, f in parsed]
+        custom_node_interface = "interface CustomNode"
+        assert custom_node_interface in types
+        assert (
+            '"""The ID of the object"""\n  id: ID!'
+            == fields[types.index(custom_node_interface)]
+        )
+        user_type = "type User implements CustomNode"
+        assert user_type in types
+        assert (
+            '"""The ID of the object"""\n  id: ID!\n  name: String'
+            == fields[types.index(user_type)]
+        )
+
+    def test_get_by_id(self):
+        query = """query {
+            user(id: "my global primary key in clear 3") {
+                id
+                name
+            }
+        }"""
+        result = graphql_sync(self.graphql_schema, query)
+        assert not result.errors
+        assert result.data["user"]["id"] == self.user_list[2]["id"]
+        assert result.data["user"]["name"] == self.user_list[2]["name"]
+
+
+class TestCustomGlobalID:
+    def setup(self):
+        self.user_list = [
+            {"id": 1, "name": "First"},
+            {"id": 2, "name": "Second"},
+            {"id": 3, "name": "Third"},
+            {"id": 4, "name": "Fourth"},
+        ]
+        self.users = {user["id"]: user for user in self.user_list}
+
+        class CustomGlobalIDType(BaseGlobalIDType):
+            """
+            Global id that is simply and integer in clear.
+            """
+
+            graphene_type = Int
+
+            @classmethod
+            def resolve_global_id(cls, info, global_id):
+                _type = info.return_type.graphene_type._meta.name
+                return _type, global_id
+
+            @classmethod
+            def to_global_id(cls, _type, _id):
+                return _id
+
+        class CustomNode(Node):
+            class Meta:
+                global_id_type = CustomGlobalIDType
+
+        class User(ObjectType):
+            class Meta:
+                interfaces = [CustomNode]
+
+            name = String()
+
+            @classmethod
+            def get_node(cls, _type, _id):
+                return self.users[_id]
+
+        class RootQuery(ObjectType):
+            user = CustomNode.Field(User)
+
+        self.schema = Schema(query=RootQuery, types=[User])
+        self.graphql_schema = self.schema.graphql_schema
+
+    def test_str_schema_correct(self):
+        """
+        Check that the schema has the expected and custom node interface and user type and that they both use UUIDs
+        """
+        parsed = re.findall(r"(.+) \{\n\s*([\w\W]*?)\n\}", str(self.schema))
+        types = [t for t, f in parsed]
+        fields = [f for t, f in parsed]
+        custom_node_interface = "interface CustomNode"
+        assert custom_node_interface in types
+        assert (
+            '"""The ID of the object"""\n  id: Int!'
+            == fields[types.index(custom_node_interface)]
+        )
+        user_type = "type User implements CustomNode"
+        assert user_type in types
+        assert (
+            '"""The ID of the object"""\n  id: Int!\n  name: String'
+            == fields[types.index(user_type)]
+        )
+
+    def test_get_by_id(self):
+        query = """query {
+            user(id: 2) {
+                id
+                name
+            }
+        }"""
+        result = graphql_sync(self.graphql_schema, query)
+        assert not result.errors
+        assert result.data["user"]["id"] == self.user_list[1]["id"]
+        assert result.data["user"]["name"] == self.user_list[1]["name"]
+
+
+class TestIncompleteCustomGlobalID:
+    def setup(self):
+        self.user_list = [
+            {"id": 1, "name": "First"},
+            {"id": 2, "name": "Second"},
+            {"id": 3, "name": "Third"},
+            {"id": 4, "name": "Fourth"},
+        ]
+        self.users = {user["id"]: user for user in self.user_list}
+
+    def test_must_define_to_global_id(self):
+        """
+        Test that if the `to_global_id` method is not defined, we can query the object, but we can't request its ID.
+        """
+
+        class CustomGlobalIDType(BaseGlobalIDType):
+            graphene_type = Int
+
+            @classmethod
+            def resolve_global_id(cls, info, global_id):
+                _type = info.return_type.graphene_type._meta.name
+                return _type, global_id
+
+        class CustomNode(Node):
+            class Meta:
+                global_id_type = CustomGlobalIDType
+
+        class User(ObjectType):
+            class Meta:
+                interfaces = [CustomNode]
+
+            name = String()
+
+            @classmethod
+            def get_node(cls, _type, _id):
+                return self.users[_id]
+
+        class RootQuery(ObjectType):
+            user = CustomNode.Field(User)
+
+        self.schema = Schema(query=RootQuery, types=[User])
+        self.graphql_schema = self.schema.graphql_schema
+
+        query = """query {
+            user(id: 2) {
+                name
+            }
+        }"""
+        result = graphql_sync(self.graphql_schema, query)
+        assert not result.errors
+        assert result.data["user"]["name"] == self.user_list[1]["name"]
+
+        query = """query {
+            user(id: 2) {
+                id
+                name
+            }
+        }"""
+        result = graphql_sync(self.graphql_schema, query)
+        assert result.errors is not None
+        assert len(result.errors) == 1
+        assert result.errors[0].path == ["user", "id"]
+
+    def test_must_define_resolve_global_id(self):
+        """
+        Test that if the `resolve_global_id` method is not defined, we can't query the object by ID.
+        """
+
+        class CustomGlobalIDType(BaseGlobalIDType):
+            graphene_type = Int
+
+            @classmethod
+            def to_global_id(cls, _type, _id):
+                return _id
+
+        class CustomNode(Node):
+            class Meta:
+                global_id_type = CustomGlobalIDType
+
+        class User(ObjectType):
+            class Meta:
+                interfaces = [CustomNode]
+
+            name = String()
+
+            @classmethod
+            def get_node(cls, _type, _id):
+                return self.users[_id]
+
+        class RootQuery(ObjectType):
+            user = CustomNode.Field(User)
+
+        self.schema = Schema(query=RootQuery, types=[User])
+        self.graphql_schema = self.schema.graphql_schema
+
+        query = """query {
+            user(id: 2) {
+                id
+                name
+            }
+        }"""
+        result = graphql_sync(self.graphql_schema, query)
+        assert result.errors is not None
+        assert len(result.errors) == 1
+        assert result.errors[0].path == ["user"]
diff --git a/graphene/relay/tests/test_node.py b/graphene/relay/tests/test_node.py
index 6b310fde..e7564566 100644
--- a/graphene/relay/tests/test_node.py
+++ b/graphene/relay/tests/test_node.py
@@ -55,6 +55,7 @@ def test_node_good():
     assert "id" in MyNode._meta.fields
     assert is_node(MyNode)
     assert not is_node(object)
+    assert not is_node("node")
 
 
 def test_node_query():