diff --git a/.isort.cfg b/.isort.cfg
index d4ed37be..76c6f842 100644
--- a/.isort.cfg
+++ b/.isort.cfg
@@ -1,2 +1,2 @@
 [settings]
-known_third_party = aniso8601,graphql,graphql_relay,promise,pytest,pytz,pyutils,setuptools,six,snapshottest,sphinx_graphene_theme
+known_third_party = aniso8601,graphql,graphql_relay,promise,pytest,pytz,pyutils,setuptools,snapshottest,sphinx_graphene_theme
diff --git a/graphene/pyutils/compat.py b/graphene/pyutils/compat.py
index 3d3ce2fe..2581446b 100644
--- a/graphene/pyutils/compat.py
+++ b/graphene/pyutils/compat.py
@@ -1,7 +1,5 @@
 from __future__ import absolute_import
 
-import six
-
 from graphql.pyutils.compat import Enum
 
 try:
@@ -9,13 +7,6 @@ try:
 except ImportError:
     from .signature import signature
 
-if six.PY2:
 
-    def func_name(func):
-        return func.func_name
-
-
-else:
-
-    def func_name(func):
-        return func.__name__
+def func_name(func):
+    return func.__name__
diff --git a/graphene/test/__init__.py b/graphene/test/__init__.py
index dab3b51b..7d554fb6 100644
--- a/graphene/test/__init__.py
+++ b/graphene/test/__init__.py
@@ -1,5 +1,4 @@
 from promise import Promise, is_thenable
-import six
 from graphql.error import format_error as format_graphql_error
 from graphql.error import GraphQLError
 
@@ -9,8 +8,7 @@ from graphene.types.schema import Schema
 def default_format_error(error):
     if isinstance(error, GraphQLError):
         return format_graphql_error(error)
-
-    return {"message": six.text_type(error)}
+    return {"message": str(error)}
 
 
 def format_execution_result(execution_result, format_error):
diff --git a/graphene/types/base.py b/graphene/types/base.py
index f43feb47..3bbebbe3 100644
--- a/graphene/types/base.py
+++ b/graphene/types/base.py
@@ -1,9 +1,7 @@
 from ..utils.subclass_with_meta import SubclassWithMeta
 from ..utils.trim_docstring import trim_docstring
-import six
 
-if six.PY3:
-    from typing import Type
+from typing import Type
 
 
 class BaseOptions(object):
diff --git a/graphene/types/datetime.py b/graphene/types/datetime.py
index 3519d76d..ca96547f 100644
--- a/graphene/types/datetime.py
+++ b/graphene/types/datetime.py
@@ -4,7 +4,6 @@ import datetime
 
 from aniso8601 import parse_date, parse_datetime, parse_time
 from graphql.language import ast
-from six import string_types
 
 from .scalars import Scalar
 
@@ -35,7 +34,7 @@ class Date(Scalar):
         try:
             if isinstance(value, datetime.date):
                 return value
-            elif isinstance(value, string_types):
+            elif isinstance(value, str):
                 return parse_date(value)
         except ValueError:
             return None
@@ -65,7 +64,7 @@ class DateTime(Scalar):
         try:
             if isinstance(value, datetime.datetime):
                 return value
-            elif isinstance(value, string_types):
+            elif isinstance(value, str):
                 return parse_datetime(value)
         except ValueError:
             return None
@@ -95,7 +94,7 @@ class Time(Scalar):
         try:
             if isinstance(value, datetime.time):
                 return value
-            elif isinstance(value, string_types):
+            elif isinstance(value, str):
                 return parse_time(value)
         except ValueError:
             return None
diff --git a/graphene/types/enum.py b/graphene/types/enum.py
index 8c95efbe..38dada0f 100644
--- a/graphene/types/enum.py
+++ b/graphene/types/enum.py
@@ -1,7 +1,5 @@
 from collections import OrderedDict
 
-import six
-
 from graphene.utils.subclass_with_meta import SubclassWithMeta_Meta
 
 from ..pyutils.compat import Enum as PyEnum
@@ -66,7 +64,7 @@ class EnumMeta(SubclassWithMeta_Meta):
         return type(meta_class.enum.__name__, (Enum,), {"Meta": meta_class})
 
 
-class Enum(six.with_metaclass(EnumMeta, UnmountedType, BaseType)):
+class Enum(UnmountedType, BaseType, metaclass=EnumMeta):
     """
     Enum type definition
 
diff --git a/graphene/types/scalars.py b/graphene/types/scalars.py
index c5f43787..769c406f 100644
--- a/graphene/types/scalars.py
+++ b/graphene/types/scalars.py
@@ -1,11 +1,9 @@
-import six
 from graphql.language.ast import BooleanValue, FloatValue, IntValue, StringValue
 
 from .base import BaseOptions, BaseType
 from .unmountedtype import UnmountedType
 
-if six.PY3:
-    from typing import Any
+from typing import Any
 
 
 class ScalarOptions(BaseOptions):
@@ -114,7 +112,7 @@ class String(Scalar):
     def coerce_string(value):
         if isinstance(value, bool):
             return u"true" if value else u"false"
-        return six.text_type(value)
+        return str(value)
 
     serialize = coerce_string
     parse_value = coerce_string
diff --git a/graphene/types/tests/test_enum.py b/graphene/types/tests/test_enum.py
index 6086f54c..b29764f2 100644
--- a/graphene/types/tests/test_enum.py
+++ b/graphene/types/tests/test_enum.py
@@ -1,5 +1,3 @@
-import six
-
 from ..argument import Argument
 from ..enum import Enum, PyEnum
 from ..field import Field
@@ -115,8 +113,6 @@ def test_enum_from_builtin_enum_accepts_lambda_description():
 
 
 def test_enum_from_python3_enum_uses_enum_doc():
-    if not six.PY3:
-        return
 
     from enum import Enum as PyEnum
 
diff --git a/graphene/types/utils.py b/graphene/types/utils.py
index b026355b..a7e23572 100644
--- a/graphene/types/utils.py
+++ b/graphene/types/utils.py
@@ -2,8 +2,6 @@ import inspect
 from collections import OrderedDict
 from functools import partial
 
-from six import string_types
-
 from ..utils.module_loading import import_string
 from .mountedtype import MountedType
 from .unmountedtype import UnmountedType
@@ -39,7 +37,7 @@ def yank_fields_from_attrs(attrs, _as=None, sort=True):
 
 
 def get_type(_type):
-    if isinstance(_type, string_types):
+    if isinstance(_type, str):
         return import_string(_type)
     if inspect.isfunction(_type) or isinstance(_type, partial):
         return _type()
diff --git a/graphene/types/uuid.py b/graphene/types/uuid.py
index 0628200b..d6d35eed 100644
--- a/graphene/types/uuid.py
+++ b/graphene/types/uuid.py
@@ -1,5 +1,4 @@
 from __future__ import absolute_import
-import six
 from uuid import UUID as _UUID
 
 from graphql.language import ast
@@ -15,7 +14,7 @@ class UUID(Scalar):
 
     @staticmethod
     def serialize(uuid):
-        if isinstance(uuid, six.string_types):
+        if isinstance(uuid, str):
             uuid = _UUID(uuid)
 
         assert isinstance(uuid, _UUID), "Expected UUID instance, received {}".format(
diff --git a/graphene/utils/annotate.py b/graphene/utils/annotate.py
index 43a26ef6..f62586d6 100644
--- a/graphene/utils/annotate.py
+++ b/graphene/utils/annotate.py
@@ -1,11 +1,9 @@
-import six
-
 from ..pyutils.compat import func_name, signature
 from .deprecated import warn_deprecation
 
 
 def annotate(_func=None, _trigger_warning=True, **annotations):
-    if not six.PY2 and _trigger_warning:
+    if _trigger_warning:
         warn_deprecation(
             "annotate is intended for use in Python 2 only, as you can use type annotations Python 3.\n"
             "Read more in https://docs.python.org/3/library/typing.html"
diff --git a/graphene/utils/subclass_with_meta.py b/graphene/utils/subclass_with_meta.py
index 01fc5375..600de3d8 100644
--- a/graphene/utils/subclass_with_meta.py
+++ b/graphene/utils/subclass_with_meta.py
@@ -1,7 +1,5 @@
 from inspect import isclass
 
-import six
-
 from ..pyutils.init_subclass import InitSubclassMeta
 from .props import props
 
@@ -18,7 +16,7 @@ class SubclassWithMeta_Meta(InitSubclassMeta):
         return "<{} meta={}>".format(cls.__name__, repr(cls._meta))
 
 
-class SubclassWithMeta(six.with_metaclass(SubclassWithMeta_Meta)):
+class SubclassWithMeta(metaclass=SubclassWithMeta_Meta):
     """This class improves __init_subclass__ to receive automatically the options from meta"""
 
     # We will only have the metaclass in Python 2
diff --git a/setup.py b/setup.py
index c0c65f61..56d3cdd0 100644
--- a/setup.py
+++ b/setup.py
@@ -55,7 +55,6 @@ tests_require = [
     "snapshottest",
     "coveralls",
     "promise",
-    "six",
     "mock",
     "pytz",
     "iso8601",
@@ -86,7 +85,6 @@ setup(
     keywords="api graphql protocol rest relay graphene",
     packages=find_packages(exclude=["tests", "tests.*", "examples"]),
     install_requires=[
-        "six>=1.10.0,<2",
         "graphql-core>=2.1,<3",
         "graphql-relay>=2,<3",
         "aniso8601>=3,<=7",
diff --git a/tox.ini b/tox.ini
index be45ceea..0320b4d6 100644
--- a/tox.ini
+++ b/tox.ini
@@ -32,7 +32,6 @@ commands =
 [testenv:mypy]
 deps =
     mypy
-    types-six
 commands =
     mypy graphene