diff --git a/Tests/test_file_libtiff.py b/Tests/test_file_libtiff.py
index c9f7d67c3..3f2e5dbc1 100644
--- a/Tests/test_file_libtiff.py
+++ b/Tests/test_file_libtiff.py
@@ -824,14 +824,12 @@ class TestFileLibTiff(LibTiffTestCase):
             assert_image_similar_tofile(im, "Tests/images/pil_sample_cmyk.jpg", 0.5)
 
     @pytest.mark.valgrind_known_error(reason="Known Failing")
-    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_strip_ycbcr_jpeg_2x2_sampling(self):
         infile = "Tests/images/tiff_strip_ycbcr_jpeg_2x2_sampling.tif"
         with Image.open(infile) as im:
             assert_image_similar_tofile(im, "Tests/images/flower.jpg", 0.5)
 
     @pytest.mark.valgrind_known_error(reason="Known Failing")
-    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_strip_ycbcr_jpeg_1x1_sampling(self):
         infile = "Tests/images/tiff_strip_ycbcr_jpeg_1x1_sampling.tif"
         with Image.open(infile) as im:
@@ -843,14 +841,12 @@ class TestFileLibTiff(LibTiffTestCase):
             assert_image_similar_tofile(im, "Tests/images/pil_sample_cmyk.jpg", 0.5)
 
     @pytest.mark.valgrind_known_error(reason="Known Failing")
-    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_tiled_ycbcr_jpeg_1x1_sampling(self):
         infile = "Tests/images/tiff_tiled_ycbcr_jpeg_1x1_sampling.tif"
         with Image.open(infile) as im:
             assert_image_equal_tofile(im, "Tests/images/flower2.jpg")
 
     @pytest.mark.valgrind_known_error(reason="Known Failing")
-    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_tiled_ycbcr_jpeg_2x2_sampling(self):
         infile = "Tests/images/tiff_tiled_ycbcr_jpeg_2x2_sampling.tif"
         with Image.open(infile) as im:
diff --git a/src/PIL/TiffImagePlugin.py b/src/PIL/TiffImagePlugin.py
index 19bcf4419..24821d130 100644
--- a/src/PIL/TiffImagePlugin.py
+++ b/src/PIL/TiffImagePlugin.py
@@ -1324,6 +1324,15 @@ class TiffImageFile(ImageFile.ImageFile):
             if ";16L" in rawmode:
                 rawmode = rawmode.replace(";16L", ";16N")
 
+            # YCbCr images with new jpeg compression with pixels in one plane
+            # unpacked straight into RGB values
+            if (
+                photo == 6
+                and self._compression == "jpeg"
+                and self._planar_configuration == 1
+            ):
+                rawmode = "RGB"
+
             # Offset in the tile tuple is 0, we go from 0,0 to
             # w,h, and we only do this once -- eds
             a = (rawmode, self._compression, False, self.tag_v2.offset)
diff --git a/src/libImaging/TiffDecode.c b/src/libImaging/TiffDecode.c
index 232278985..e20f57596 100644
--- a/src/libImaging/TiffDecode.c
+++ b/src/libImaging/TiffDecode.c
@@ -407,6 +407,7 @@ ImagingLibTiffDecode(
     char *mode = "r";
     TIFF *tiff;
     uint16 photometric = 0;  // init to not PHOTOMETRIC_YCBCR
+    uint16 compression;
     int isYCbCr = 0;
     uint16 planarconfig = 0;
     int planes = 1;
@@ -509,9 +510,17 @@ ImagingLibTiffDecode(
 
 
     TIFFGetField(tiff, TIFFTAG_PHOTOMETRIC, &photometric);
-    isYCbCr = photometric == PHOTOMETRIC_YCBCR;
+    TIFFGetField(tiff, TIFFTAG_COMPRESSION, &compression);
     TIFFGetFieldDefaulted(tiff, TIFFTAG_PLANARCONFIG, &planarconfig);
 
+    isYCbCr = photometric == PHOTOMETRIC_YCBCR;
+
+    if (isYCbCr && compression == COMPRESSION_JPEG && planarconfig == PLANARCONFIG_CONTIG) {
+        // If using new JPEG compression, let libjpeg do RGB convertion
+        TIFFSetField(tiff, TIFFTAG_JPEGCOLORMODE, JPEGCOLORMODE_RGB);
+        isYCbCr = 0;
+    }
+
     // YCbCr data is read as RGB by libtiff and we don't need to worry about planar storage in that case
     // if number of bands is 1, there is no difference with contig case
     if (planarconfig == PLANARCONFIG_SEPARATE &&