diff --git a/Tests/images/crash-81154a65438ba5aaeca73fd502fa4850fbde60f8.tif b/Tests/images/crash-81154a65438ba5aaeca73fd502fa4850fbde60f8.tif
new file mode 100644
index 000000000..56e824199
Binary files /dev/null and b/Tests/images/crash-81154a65438ba5aaeca73fd502fa4850fbde60f8.tif differ
diff --git a/Tests/test_tiff_crashes.py b/Tests/test_tiff_crashes.py
index 7b01d458e..a8e378ec1 100644
--- a/Tests/test_tiff_crashes.py
+++ b/Tests/test_tiff_crashes.py
@@ -34,6 +34,7 @@ from .helper import on_ci
         "Tests/images/crash-f46f5b2f43c370fe65706c11449f567ecc345e74.tif",
         "Tests/images/crash-63b1dffefc8c075ddc606c0a2f5fdc15ece78863.tif",
         "Tests/images/crash-74d2a78403a5a59db1fb0a2b8735ac068a75f6e3.tif",
+        "Tests/images/crash-81154a65438ba5aaeca73fd502fa4850fbde60f8.tif",
 
     ],
 )
diff --git a/src/PIL/TiffImagePlugin.py b/src/PIL/TiffImagePlugin.py
index 24821d130..9d821dcf9 100644
--- a/src/PIL/TiffImagePlugin.py
+++ b/src/PIL/TiffImagePlugin.py
@@ -1250,6 +1250,10 @@ class TiffImageFile(ImageFile.ImageFile):
         if bps_count > len(bps_tuple) and len(bps_tuple) == 1:
             bps_tuple = bps_tuple * bps_count
 
+        samplesPerPixel = self.tag_v2.get(SAMPLESPERPIXEL, 1)
+        if len(bps_tuple) != samplesPerPixel:
+            raise SyntaxError("unknown data organization")
+
         # mode: check photometric interpretation and bits per pixel
         key = (
             self.tag_v2.prefix,