diff --git a/.github/mergify.yml b/.github/mergify.yml
index 9bb089615..26a401798 100644
--- a/.github/mergify.yml
+++ b/.github/mergify.yml
@@ -7,7 +7,7 @@ pull_request_rules:
       - status-success=Test Successful
       - status-success=Docker Test Successful
       - status-success=Windows Test Successful
-      - status-success=MinGW
+      - status-success=MSYS2 Test Successful
       - status-success=Cygwin Test Successful
     actions:
       merge:
diff --git a/.github/workflows/test-mingw.yml b/.github/workflows/test-mingw.yml
deleted file mode 100644
index bb6d7dc37..000000000
--- a/.github/workflows/test-mingw.yml
+++ /dev/null
@@ -1,93 +0,0 @@
-name: Test MinGW
-
-on:
-  push:
-    branches:
-      - "**"
-    paths-ignore:
-      - ".github/workflows/docs.yml"
-      - ".github/workflows/wheels*"
-      - ".gitmodules"
-      - "docs/**"
-      - "wheels/**"
-  pull_request:
-    paths-ignore:
-      - ".github/workflows/docs.yml"
-      - ".github/workflows/wheels*"
-      - ".gitmodules"
-      - "docs/**"
-      - "wheels/**"
-  workflow_dispatch:
-
-permissions:
-  contents: read
-
-concurrency:
-  group: ${{ github.workflow }}-${{ github.ref }}
-  cancel-in-progress: true
-
-env:
-  COVERAGE_CORE: sysmon
-
-jobs:
-  build:
-    runs-on: windows-latest
-
-    defaults:
-      run:
-        shell: bash.exe --login -eo pipefail "{0}"
-    env:
-      MSYSTEM: MINGW64
-      CHERE_INVOKING: 1
-
-    timeout-minutes: 30
-    name: "MinGW"
-
-    steps:
-      - name: Checkout Pillow
-        uses: actions/checkout@v4
-        with:
-          persist-credentials: false
-
-      - name: Set up shell
-        run: echo "C:\msys64\usr\bin\" >> $env:GITHUB_PATH
-        shell: pwsh
-
-      - name: Install dependencies
-        run: |
-          pacman -S --noconfirm \
-              mingw-w64-x86_64-freetype \
-              mingw-w64-x86_64-gcc \
-              mingw-w64-x86_64-ghostscript \
-              mingw-w64-x86_64-lcms2 \
-              mingw-w64-x86_64-libimagequant \
-              mingw-w64-x86_64-libjpeg-turbo \
-              mingw-w64-x86_64-libraqm \
-              mingw-w64-x86_64-libtiff \
-              mingw-w64-x86_64-libwebp \
-              mingw-w64-x86_64-openjpeg2 \
-              mingw-w64-x86_64-python-numpy \
-              mingw-w64-x86_64-python-olefile \
-              mingw-w64-x86_64-python-pip \
-              mingw-w64-x86_64-python-pytest \
-              mingw-w64-x86_64-python-pytest-cov \
-              mingw-w64-x86_64-python-pytest-timeout \
-              mingw-w64-x86_64-python-pyqt6
-
-          pushd depends && ./install_extra_test_images.sh && popd
-
-      - name: Build Pillow
-        run: CFLAGS="-coverage" python3 -m pip install .
-
-      - name: Test Pillow
-        run: |
-          python3 selftest.py --installed
-          .ci/test.sh
-
-      - name: Upload coverage
-        uses: codecov/codecov-action@v5
-        with:
-          files: ./coverage.xml
-          flags: GHA_Windows
-          name: "MSYS2 MinGW"
-          token: ${{ secrets.CODECOV_ORG_TOKEN }}
diff --git a/.github/workflows/test-msys2.yml b/.github/workflows/test-msys2.yml
new file mode 100644
index 000000000..87e945576
--- /dev/null
+++ b/.github/workflows/test-msys2.yml
@@ -0,0 +1,115 @@
+name: Test MSYS2
+
+on:
+  push:
+    branches:
+      - "**"
+    paths-ignore:
+      - ".github/workflows/docs.yml"
+      - ".github/workflows/wheels*"
+      - ".gitmodules"
+      - "docs/**"
+      - "wheels/**"
+  pull_request:
+    paths-ignore:
+      - ".github/workflows/docs.yml"
+      - ".github/workflows/wheels*"
+      - ".gitmodules"
+      - "docs/**"
+      - "wheels/**"
+  workflow_dispatch:
+
+permissions:
+  contents: read
+
+concurrency:
+  group: ${{ github.workflow }}-${{ github.ref }}
+  cancel-in-progress: true
+
+env:
+  COVERAGE_CORE: sysmon
+
+jobs:
+  build:
+    runs-on: windows-latest
+    strategy:
+      fail-fast: false
+      matrix:
+        include:
+          # skip to save CI time:
+          # see https://github.com/python-pillow/Pillow/pull/6888#issuecomment-1400392821
+          # - msystem: "UCRT64"
+          - msystem: "CLANG64"
+          - msystem: "MINGW64"
+    defaults:
+      run:
+        shell: bash.exe --login -eo pipefail "{0}"
+    env:
+      MSYSTEM: ${{ matrix.msystem }}
+      CHERE_INVOKING: 1
+
+    timeout-minutes: 30
+    name: MSYS2 ${{ matrix.msystem }}
+
+    steps:
+      - name: Checkout Pillow
+        uses: actions/checkout@v4
+        with:
+          persist-credentials: false
+
+      - name: Set up shell
+        run: echo "C:\msys64\usr\bin\" >> $env:GITHUB_PATH
+        shell: pwsh
+
+      - name: Install dependencies
+        run: |
+          pacman -S --noconfirm \
+              make \
+              pactoys \
+              subversion
+
+          pacboy -S --noconfirm \
+              freetype:p \
+              gcc:p \
+              ghostscript:p \
+              lcms2:p \
+              libimagequant:p \
+              libjpeg-turbo:p \
+              libraqm:p \
+              libtiff:p \
+              libwebp:p \
+              openjpeg2:p \
+              python-numpy:p \
+              python-olefile:p \
+              python-pip:p \
+              python-pyqt6:p
+
+          python3 -m pip install pyroma pytest pytest-cov pytest-timeout
+
+          pushd depends && ./install_extra_test_images.sh && popd
+
+      - name: Build Pillow
+        run: .ci/build.sh
+
+      - name: Test Pillow
+        run: .ci/test.sh
+
+      - name: After success
+        run: .ci/after_success.sh
+
+      - name: Upload coverage
+        uses: codecov/codecov-action@v5
+        with:
+          files: ./coverage.xml
+          flags: GHA_Windows
+          name: MSYS2 ${{ matrix.msystem }}
+
+  success:
+    permissions:
+      contents: none
+    needs: build
+    runs-on: ubuntu-latest
+    name: MSYS2 Test Successful
+    steps:
+      - name: Success
+        run: echo MSYS2 Test Successful
diff --git a/docs/installation/building-from-source.rst b/docs/installation/building-from-source.rst
index 2790bc2e6..ab54d3ef0 100644
--- a/docs/installation/building-from-source.rst
+++ b/docs/installation/building-from-source.rst
@@ -162,32 +162,44 @@ Many of Pillow's features require external libraries:
 
 .. tab:: Windows using MSYS2/MinGW
 
-    To build Pillow using MSYS2, make sure you run the **MSYS2 MinGW 32-bit** or
-    **MSYS2 MinGW 64-bit** console, *not* **MSYS2** directly.
+    The following instructions are for the **MSYS2 UCRT64** system.
+    To build Pillow on one of the other MSYS2 systems, replace all occurences of
+    ``mingw-w64-ucrt-x86_64`` with the corresponding prefix:
 
-    The following instructions target the 64-bit build, for 32-bit
-    replace all occurrences of ``mingw-w64-x86_64-`` with ``mingw-w64-i686-``.
+    .. list-table::
+        :header-rows: 1
+
+        * - MSYS2 system
+          - Package prefix
+        * - **UCRT64**
+          - ``mingw-w64-ucrt-x86_64``
+        * - **CLANG64**
+          - ``mingw-w64-clang-x86_64``
+        * - **MINGW64**
+          - ``mingw-w64-x86_64``
+
+    Installing in **MSYS2 MSYS** is not supported.
 
     Make sure you have Python and GCC installed::
 
         pacman -S \
-            mingw-w64-x86_64-gcc \
-            mingw-w64-x86_64-python3 \
-            mingw-w64-x86_64-python3-pip \
-            mingw-w64-x86_64-python3-setuptools
+            mingw-w64-ucrt-x86_64-gcc \
+            mingw-w64-ucrt-x86_64-python3 \
+            mingw-w64-ucrt-x86_64-python3-pip \
+            mingw-w64-ucrt-x86_64-python3-setuptools
 
-    Prerequisites are installed on **MSYS2 MinGW 64-bit** with::
+    Prerequisites are installed on **MSYS2 UCRT64** with::
 
         pacman -S \
-            mingw-w64-x86_64-libjpeg-turbo \
-            mingw-w64-x86_64-zlib \
-            mingw-w64-x86_64-libtiff \
-            mingw-w64-x86_64-freetype \
-            mingw-w64-x86_64-lcms2 \
-            mingw-w64-x86_64-libwebp \
-            mingw-w64-x86_64-openjpeg2 \
-            mingw-w64-x86_64-libimagequant \
-            mingw-w64-x86_64-libraqm
+            mingw-w64-ucrt-x86_64-libjpeg-turbo \
+            mingw-w64-ucrt-x86_64-zlib \
+            mingw-w64-ucrt-x86_64-libtiff \
+            mingw-w64-ucrt-x86_64-freetype \
+            mingw-w64-ucrt-x86_64-lcms2 \
+            mingw-w64-ucrt-x86_64-libwebp \
+            mingw-w64-ucrt-x86_64-openjpeg2 \
+            mingw-w64-ucrt-x86_64-libimagequant \
+            mingw-w64-ucrt-x86_64-libraqm
 
 .. tab:: FreeBSD
 
diff --git a/docs/installation/platform-support.rst b/docs/installation/platform-support.rst
index 9eafad3c4..cde2a3750 100644
--- a/docs/installation/platform-support.rst
+++ b/docs/installation/platform-support.rst
@@ -53,7 +53,7 @@ These platforms are built and tested for every change.
 | Windows Server 2022              | 3.10, 3.11, 3.12, 3.13,    | x86-64              |
 |                                  | PyPy3                      |                     |
 |                                  +----------------------------+---------------------+
-|                                  | 3.12 (MinGW)               | x86-64              |
+|                                  | 3.12 (CLANG64, MINGW64)    | x86-64              |
 |                                  +----------------------------+---------------------+
 |                                  | 3.9 (Cygwin)               | x86-64              |
 +----------------------------------+----------------------------+---------------------+