diff --git a/.github/workflows/wheels-dependencies.sh b/.github/workflows/wheels-dependencies.sh
index c79cd2f17..f250cda20 100755
--- a/.github/workflows/wheels-dependencies.sh
+++ b/.github/workflows/wheels-dependencies.sh
@@ -276,6 +276,10 @@ function build {
     build_simple libxcb $LIBXCB_VERSION https://www.x.org/releases/individual/lib
 
     build_libjpeg_turbo
+    if [[ "$AUDITWHEEL_ARCH" == "ppc64le" ]]; then
+        return
+    fi
+
     if [[ -n "$IS_MACOS" ]]; then
         # Custom tiff build to include jpeg; by default, configure won't include
         # headers/libs in the custom macOS/iOS prefix. Explicitly disable webp,
diff --git a/checks/check_wheel.py b/checks/check_wheel.py
index 937722c4b..ba27674df 100644
--- a/checks/check_wheel.py
+++ b/checks/check_wheel.py
@@ -27,11 +27,16 @@ def test_wheel_modules() -> None:
         # tkinter is not available on iOS
         expected_modules.remove("tkinter")
 
+    elif platform.processor() == "ppc64le":
+        expected_modules -= {"freetype2", "littlecms2", "webp", "avif"}
+
     assert set(features.get_supported_modules()) == expected_modules
 
 
 def test_wheel_codecs() -> None:
     expected_codecs = {"jpg", "jpg_2000", "zlib", "libtiff"}
+    if platform.processor() == "ppc64le":
+        expected_codecs -= {"jpg_2000", "libtiff"}
 
     assert set(features.get_supported_codecs()) == expected_codecs
 
@@ -54,5 +59,7 @@ def test_wheel_features() -> None:
         # Can't distribute raqm due to licensing, and there's no system version;
         # fribidi and harfbuzz won't be available if raqm isn't available.
         expected_features -= {"raqm", "fribidi", "harfbuzz"}
+    elif platform.processor() == "ppc64le":
+        expected_features -= {"raqm", "fribidi", "harfbuzz"}
 
     assert set(features.get_supported_features()) == expected_features
diff --git a/pyproject.toml b/pyproject.toml
index 137726a1c..7404718ff 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -150,6 +150,11 @@ environment.PATH = "$(pwd)/build/deps/iphonesimulator/bin:$PATH"
 select = "*-win32"
 test-requires = [  ]
 
+[[tool.cibuildwheel.overrides]]
+select = "*_ppc64le"
+config-settings = "raqm=disable fribidi=disable imagequant=disable"
+test-requires = [  ]
+
 [tool.black]
 exclude = "wheels/multibuild"