diff --git a/Tests/test_file_libtiff.py b/Tests/test_file_libtiff.py
index b5e103e39..ad0d67ce5 100644
--- a/Tests/test_file_libtiff.py
+++ b/Tests/test_file_libtiff.py
@@ -496,7 +496,7 @@ class TestFileLibTiff(LibTiffTestCase):
             pilim_load = Image.open(buffer_io)
             self.assert_image_similar(pilim, pilim_load, 0)
 
-        # save_bytesio()
+        save_bytesio()
         save_bytesio('raw')
         save_bytesio("packbits")
         save_bytesio("tiff_lzw")
diff --git a/src/PIL/TiffImagePlugin.py b/src/PIL/TiffImagePlugin.py
index ecfe8d890..2c90c0d40 100644
--- a/src/PIL/TiffImagePlugin.py
+++ b/src/PIL/TiffImagePlugin.py
@@ -1404,8 +1404,9 @@ def _save(im, fp, filename):
 
     ifd = ImageFileDirectory_v2(prefix=prefix)
 
-    compression = im.encoderinfo.get('compression',
-                                     im.info.get('compression', 'raw'))
+    compression = im.encoderinfo.get('compression', im.info.get('compression'))
+    if compression is None:
+        compression = 'raw'
 
     libtiff = WRITE_LIBTIFF or compression != 'raw'