diff --git a/Tests/test_image_fromqpixmap.py b/Tests/test_image_fromqpixmap.py
index 543b74bbf..d03f2d0e4 100644
--- a/Tests/test_image_fromqpixmap.py
+++ b/Tests/test_image_fromqpixmap.py
@@ -1,5 +1,5 @@
 from helper import unittest, PillowTestCase, hopper
-from test_imageqt import PillowQtTestCase, PillowQPixmapTestCase
+from test_imageqt import PillowQPixmapTestCase
 
 from PIL import ImageQt
 
@@ -7,10 +7,11 @@ from PIL import ImageQt
 class TestFromQPixmap(PillowQPixmapTestCase, PillowTestCase):
 
     def roundtrip(self, expected):
-        PillowQtTestCase.setUp(self)
-        result = ImageQt.fromqpixmap(ImageQt.toqpixmap(expected))
-        # Qt saves all pixmaps as rgb
-        self.assert_image_equal(result, expected.convert('RGB'))
+        def test():
+            result = ImageQt.fromqpixmap(ImageQt.toqpixmap(expected))
+            # Qt saves all pixmaps as rgb
+            self.assert_image_equal(result, expected.convert('RGB'))
+        self.executeInSeparateProcess(test)
 
     def test_sanity_1(self):
         self.roundtrip(hopper('1'))
diff --git a/Tests/test_image_toqimage.py b/Tests/test_image_toqimage.py
index c9971cf73..bb238c622 100644
--- a/Tests/test_image_toqimage.py
+++ b/Tests/test_image_toqimage.py
@@ -25,7 +25,6 @@ if ImageQt.qt_is_installed:
 class TestToQImage(PillowQtTestCase, PillowTestCase):
 
     def test_sanity(self):
-        PillowQtTestCase.setUp(self)
         for mode in ('RGB', 'RGBA', 'L', 'P', '1'):
             src = hopper(mode)
             data = ImageQt.toqimage(src)
@@ -61,12 +60,12 @@ class TestToQImage(PillowQtTestCase, PillowTestCase):
             self.assert_image_equal(reloaded, src)
 
     def test_segfault(self):
-        PillowQtTestCase.setUp(self)
-
-        app = QApplication([])
-        ex = Example()
-        assert(app)  # Silence warning
-        assert(ex)   # Silence warning
+        def test():
+            app = QApplication([])
+            ex = Example()
+            assert(app)  # Silence warning
+            assert(ex)   # Silence warning
+        self.executeInSeparateProcess(test)
 
 
 if ImageQt.qt_is_installed:
diff --git a/Tests/test_image_toqpixmap.py b/Tests/test_image_toqpixmap.py
index c6555d7ff..d3975cb67 100644
--- a/Tests/test_image_toqpixmap.py
+++ b/Tests/test_image_toqpixmap.py
@@ -1,5 +1,5 @@
 from helper import unittest, PillowTestCase, hopper
-from test_imageqt import PillowQtTestCase, PillowQPixmapTestCase
+from test_imageqt import PillowQPixmapTestCase
 
 from PIL import ImageQt
 
@@ -10,17 +10,17 @@ if ImageQt.qt_is_installed:
 class TestToQPixmap(PillowQPixmapTestCase, PillowTestCase):
 
     def test_sanity(self):
-        PillowQtTestCase.setUp(self)
+        def test():
+            for mode in ('1', 'RGB', 'RGBA', 'L', 'P'):
+                data = ImageQt.toqpixmap(hopper(mode))
 
-        for mode in ('1', 'RGB', 'RGBA', 'L', 'P'):
-            data = ImageQt.toqpixmap(hopper(mode))
+                self.assertIsInstance(data, QPixmap)
+                self.assertFalse(data.isNull())
 
-            self.assertIsInstance(data, QPixmap)
-            self.assertFalse(data.isNull())
-
-            # Test saving the file
-            tempfile = self.tempfile('temp_{}.png'.format(mode))
-            data.save(tempfile)
+                # Test saving the file
+                tempfile = self.tempfile('temp_{}.png'.format(mode))
+                data.save(tempfile)
+        self.executeInSeparateProcess(test)
 
 
 if __name__ == '__main__':
diff --git a/Tests/test_imageqt.py b/Tests/test_imageqt.py
index cf9712ace..04bfef203 100644
--- a/Tests/test_imageqt.py
+++ b/Tests/test_imageqt.py
@@ -2,6 +2,7 @@ from helper import unittest, PillowTestCase, hopper
 
 from PIL import ImageQt
 
+import multiprocessing
 
 if ImageQt.qt_is_installed:
     from PIL.ImageQt import qRgba
@@ -18,6 +19,21 @@ class PillowQtTestCase(object):
     def setUp(self):
         skip_if_qt_is_not_installed(self)
 
+    def executeInSeparateProcess(self, test):
+        def target():
+            if ImageQt.qt_version == '5':
+                from PyQt5.QtGui import QGuiApplication
+            elif ImageQt.qt_version == '4':
+                from PyQt4.QtGui import QGuiApplication
+            elif ImageQt.qt_version == 'side':
+                from PySide.QtGui import QGuiApplication
+            app = QGuiApplication([])
+            test()
+            app.quit()
+        p = multiprocessing.Process(target=target)
+        p.start()
+        p.join()
+
     def tearDown(self):
         pass
 
@@ -36,12 +52,6 @@ class PillowQPixmapTestCase(PillowQtTestCase):
         except ImportError:
             self.skipTest('QGuiApplication not installed')
 
-        self.app = QGuiApplication([])
-
-    def tearDown(self):
-        PillowQtTestCase.tearDown(self)
-        self.app.quit()
-
 
 class TestImageQt(PillowQtTestCase, PillowTestCase):