diff --git a/Tests/test_file_libtiff.py b/Tests/test_file_libtiff.py
index da955b3de..7d3e10c24 100644
--- a/Tests/test_file_libtiff.py
+++ b/Tests/test_file_libtiff.py
@@ -16,6 +16,7 @@ from .helper import (
     assert_image_similar,
     assert_image_similar_tofile,
     hopper,
+    is_big_endian,
     skip_unless_feature,
 )
 
@@ -813,11 +814,13 @@ class TestFileLibTiff(LibTiffTestCase):
         with Image.open(infile) as im:
             assert_image_similar_tofile(im, "Tests/images/pil_sample_cmyk.jpg", 0.5)
 
+    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_strip_ycbcr_jpeg_2x2_sampling(self):
         infile = "Tests/images/tiff_strip_ycbcr_jpeg_2x2_sampling.tif"
         with Image.open(infile) as im:
             assert_image_similar_tofile(im, "Tests/images/flower.jpg", 0.5)
 
+    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_strip_ycbcr_jpeg_1x1_sampling(self):
         infile = "Tests/images/tiff_strip_ycbcr_jpeg_1x1_sampling.tif"
         with Image.open(infile) as im:
@@ -828,16 +831,19 @@ class TestFileLibTiff(LibTiffTestCase):
         with Image.open(infile) as im:
             assert_image_similar_tofile(im, "Tests/images/pil_sample_cmyk.jpg", 0.5)
 
+    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_tiled_ycbcr_jpeg_1x1_sampling(self):
         infile = "Tests/images/tiff_tiled_ycbcr_jpeg_1x1_sampling.tif"
         with Image.open(infile) as im:
             assert_image_equal_tofile(im, "Tests/images/flower2.jpg")
 
+    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_tiled_ycbcr_jpeg_2x2_sampling(self):
         infile = "Tests/images/tiff_tiled_ycbcr_jpeg_2x2_sampling.tif"
         with Image.open(infile) as im:
             assert_image_similar_tofile(im, "Tests/images/flower.jpg", 0.5)
 
+    @pytest.mark.xfail(is_big_endian(), reason="Fails on big-endian")
     def test_old_style_jpeg(self):
         infile = "Tests/images/old-style-jpeg-compression.tif"
         with Image.open(infile) as im: