diff --git a/Tests/images/uint16_2_4660.tif b/Tests/images/uint16_2_4660.tif
new file mode 100644
index 000000000..188ff2af7
Binary files /dev/null and b/Tests/images/uint16_2_4660.tif differ
diff --git a/Tests/images/uint16_3_4660.tif b/Tests/images/uint16_3_4660.tif
new file mode 100644
index 000000000..3c2bc8658
Binary files /dev/null and b/Tests/images/uint16_3_4660.tif differ
diff --git a/Tests/images/uint16_4_4660.tif b/Tests/images/uint16_4_4660.tif
new file mode 100644
index 000000000..ae8252d78
Binary files /dev/null and b/Tests/images/uint16_4_4660.tif differ
diff --git a/Tests/images/uint16_5_4660.tif b/Tests/images/uint16_5_4660.tif
new file mode 100644
index 000000000..df92724c3
Binary files /dev/null and b/Tests/images/uint16_5_4660.tif differ
diff --git a/Tests/test_file_tiff.py b/Tests/test_file_tiff.py
index 8821fb46a..8a54f0756 100644
--- a/Tests/test_file_tiff.py
+++ b/Tests/test_file_tiff.py
@@ -874,6 +874,19 @@ class TestFileTiff:
                 with Image.open(test_file):
                     pass
 
+    def test_open_tiff_uint16_multiband(self):
+        """Test opening multiband TIFFs and reading all channels."""
+        base_value = 4660
+        for i in range(2, 6):
+            infile = f"Tests/images/uint16_{i}_{base_value}.tif"
+            im = Image.open(infile)
+            im.load()
+            pixel = [base_value + j for j in range(0, i)]
+            actual_pixel = im.getpixel((0, 0))
+            if isinstance(actual_pixel, int):
+                actual_pixel = [actual_pixel]
+            assert actual_pixel == pixel
+
 
 @pytest.mark.skipif(not is_win32(), reason="Windows only")
 class TestFileTiffW32:
diff --git a/src/PIL/TiffImagePlugin.py b/src/PIL/TiffImagePlugin.py
index 54faa59c5..e70f12526 100644
--- a/src/PIL/TiffImagePlugin.py
+++ b/src/PIL/TiffImagePlugin.py
@@ -182,6 +182,43 @@ OPEN_INFO = {
     (II, 1, (1,), 1, (12,), ()): ("I;16", "I;12"),
     (II, 0, (1,), 1, (16,), ()): ("I;16", "I;16"),
     (II, 1, (1,), 1, (16,), ()): ("I;16", "I;16"),
+    (II, 1, (1,), 1, (16, 16), (0,)): ("I;16", "I;16"),
+    (
+        II,
+        1,
+        (1,),
+        1,
+        (16, 16, 16),
+        (
+            0,
+            0,
+        ),
+    ): ("I;16", "I;16"),
+    (
+        II,
+        1,
+        (1,),
+        1,
+        (16, 16, 16, 16),
+        (
+            0,
+            0,
+            0,
+        ),
+    ): ("I;16", "I;16"),
+    (
+        II,
+        1,
+        (1,),
+        1,
+        (16, 16, 16, 16, 16),
+        (
+            0,
+            0,
+            0,
+            0,
+        ),
+    ): ("I;16", "I;16"),
     (MM, 1, (1,), 1, (16,), ()): ("I;16B", "I;16B"),
     (II, 1, (1,), 2, (16,), ()): ("I;16", "I;16R"),
     (II, 1, (2,), 1, (16,), ()): ("I", "I;16S"),