diff --git a/libImaging/Antialias.c b/libImaging/Antialias.c
index a97141013..1799e7fdc 100644
--- a/libImaging/Antialias.c
+++ b/libImaging/Antialias.c
@@ -93,9 +93,8 @@ static inline UINT8 clip8(float in)
 /* This is work around bug in GCC prior 4.9 in 64 bit mode.
    GCC generates code with partial dependency which 3 times slower.
    See: http://stackoverflow.com/a/26588074/253146 */
-#if defined(__x86_64__) && defined(__SSE__) && \
-    ! defined(__clang__) && defined(GCC_VERSION) && (GCC_VERSION < 40900) && \
-    ! defined(Py_DEBUG)
+#if defined(__x86_64__) && defined(__SSE__) &&  ! defined(__NO_INLINE__) && \
+    ! defined(__clang__) && defined(GCC_VERSION) && (GCC_VERSION < 40900)
 static float __attribute__((always_inline)) i2f(int v) {
     float x;
     __asm__("xorps %0, %0; cvtsi2ss %1, %0" : "=X"(x) : "r"(v) );