diff --git a/Tests/images/16bit.s.tif b/Tests/images/16bit.s.tif
new file mode 100644
index 000000000..f36e68d61
Binary files /dev/null and b/Tests/images/16bit.s.tif differ
diff --git a/Tests/test_file_tiff.py b/Tests/test_file_tiff.py
index 2a9132d48..4c6ae4af3 100644
--- a/Tests/test_file_tiff.py
+++ b/Tests/test_file_tiff.py
@@ -198,6 +198,11 @@ class TestFileTiff(PillowTestCase):
             self.assertEqual(b[0], b'\x01')
             self.assertEqual(b[1], b'\xe0')
 
+    def test_16bit_s(self):
+        im = Image.open('Tests/images/16bit.s.tif')
+        im.load()
+        self.assertEqual(im.mode, 'I;16S')
+
     def test_12bit_rawmode(self):
         """ Are we generating the same interpretation
         of the image as Imagemagick is? """
diff --git a/libImaging/Access.c b/libImaging/Access.c
index 292968f1c..05eb10c7c 100644
--- a/libImaging/Access.c
+++ b/libImaging/Access.c
@@ -227,6 +227,7 @@ ImagingAccessInit()
     ADD("I;16", line_16, get_pixel_16L, put_pixel_16L);
     ADD("I;16L", line_16, get_pixel_16L, put_pixel_16L);
     ADD("I;16B", line_16, get_pixel_16B, put_pixel_16B);
+    ADD("I;16S", line_16, get_pixel_16L, put_pixel_16L);
     ADD("I;32L", line_32, get_pixel_32L, put_pixel_32L);
     ADD("I;32B", line_32, get_pixel_32B, put_pixel_32B);
     ADD("F", line_32, get_pixel_32, put_pixel_32);
diff --git a/libImaging/Storage.c b/libImaging/Storage.c
index 72285970a..8a897b0c9 100644
--- a/libImaging/Storage.c
+++ b/libImaging/Storage.c
@@ -115,7 +115,7 @@ ImagingNewPrologueSubtype(const char *mode, int xsize, int ysize, int size)
         im->linesize = xsize * 4;
         im->type = IMAGING_TYPE_INT32;
 
-    } else if (strcmp(mode, "I;16") == 0 || strcmp(mode, "I;16L") == 0 \
+    } else if (strcmp(mode, "I;16") == 0 || strcmp(mode, "I;16L") == 0 || strcmp(mode, "I;16S") == 0 \
                            || strcmp(mode, "I;16B") == 0 || strcmp(mode, "I;16N") == 0)  {
         /* EXPERIMENTAL */
         /* 16-bit raw integer images */
diff --git a/libImaging/Unpack.c b/libImaging/Unpack.c
index c7b9a606c..b6011a8a0 100644
--- a/libImaging/Unpack.c
+++ b/libImaging/Unpack.c
@@ -1405,6 +1405,7 @@ static struct {
     /* storage modes */
     {"I;16",    "I;16",         16,     copy2},
     {"I;16B",   "I;16B",        16,     copy2},
+    {"I;16S",   "I;16S",        16,     copy2},
     {"I;16L",   "I;16L",        16,     copy2},
 
     {"I;16", 	"I;16N",	    16,	    unpackI16N_I16}, // LibTiff native->image endian.