diff --git a/src/instrument.js b/src/instrument.js
index e8c47f0f..00b74f05 100644
--- a/src/instrument.js
+++ b/src/instrument.js
@@ -336,10 +336,17 @@ function unliftStore(liftedStore, liftReducer) {
 export default function instrument(monitorReducer = () => null) {
   return createStore => (reducer, initialState, enhancer) => {
     function liftReducer(r) {
+      if (typeof r !== 'function') {
+        throw new Error('Expected the nextReducer to be a function.');
+      }
       return liftReducerWith(r, initialState, monitorReducer);
     }
 
     const liftedStore = createStore(liftReducer(reducer), undefined, enhancer);
+    if (liftedStore.liftedStore) {
+      throw new Error('DevTools instrument shouldn\'t be included more than once. ' +
+        'Check your store configuration.');
+    }
     return unliftStore(liftedStore, liftReducer);
   };
 }
diff --git a/test/instrument.spec.js b/test/instrument.spec.js
index 9db18896..735024af 100644
--- a/test/instrument.spec.js
+++ b/test/instrument.spec.js
@@ -1,5 +1,5 @@
 import expect, { spyOn } from 'expect';
-import { createStore } from 'redux';
+import { createStore, compose } from 'redux';
 import instrument, { ActionCreators } from '../src/instrument';
 
 function counter(state = 0, action) {
@@ -322,4 +322,15 @@ describe('instrument', () => {
       expect(importMonitoredLiftedStore.getState()).toEqual(exportedState);
     });
   });
+
+  it('throws if reducer is not a function', () => {
+    expect(() =>
+      instrument()(createStore)()
+    ).toThrow('Expected the nextReducer to be a function.');
+  });
+  it('throws if there are more than one instrument enhancer included', () => {
+    expect(() => {
+      store = createStore(counter, undefined, compose(instrument(), instrument()));
+    }).toThrow('DevTools instrument shouldn\'t be included more than once. Check your store configuration.');
+  });
 });